For most of human history, people went about their daily lives with a worm or two (or fifty) in their guts. Only in the past century, with pharmaceuticals and sanitation practices, have we made significant strides towards deworming the whole of humanity. And that’s typically been thought of as a good thing, because having too many worms in your body can–quite literally–suck the life out of you.
But is it possible to have… too few worms? Science wonders if deworming ourselves has actually led to an increase in certain chronic diseases. On this episode, we dive into Necator americanus, a.k.a. the American Hookworm, and its mysterious relationship with each of us.
We trace the hookworm’s 118-year journey from a demonized economic depressant, to its use as a desperate D.I.Y. immunosuppressant, to its potential as a medical treatment for a number of chronic diseases, everything from asthma to MS.
We’re bringing back two stories from our 2009 episode Parasites plus new research on hookworms and autoimmune diseases, reported by Molly Webster
Special thanks to Ethan Hein for the use of his remix of Mozart's Piano Concerto No. 21. Plus, Doris Pierce, and Dan and Alice Hadley.
EPISODE CREDITS:
Reported by - Pat Walters and Molly Webster
with help from - {{wREPORTERS}}
Produced by - Matt Kielty
with help from - Rebecca Rand
Fact-checking by - Diane A. Kelly
and Edited by - Arianne Wack
EPISODE CITATIONS:
Articles -
Effect of experimental hookworm infection on insulin resistance in people at risk of type 2 diabetes (https://pubmed.ncbi.nlm.nih.gov/37495576/) by Giacomin PR et al. Nat Commun. 2023 Jul 26
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First up on the podcast, Meagan Cantwell produced a segment with Contributing Correspondent Kai Kupferschmidt on the fight against deepfakes. Kupferschmidt talks with Hany Farid, professor at the University of California, Berkeley, about the never-ending battle against fake imagery and why Farid is not giving up.
Next on the show, building a tough, bio-compatible capsule for engineered bacteria. Tetsuhiro Harimoto talks about the challenges of keeping living bacteria inside a hydrogel capsule and the advantages of using engineered bacteria as sensors and medicine dispensers inside the body. (Harimoto completed this work as a postdoc at Harvard University and will start as a professor at Cornell University in the fall.)
This week’s episode was produced with help from Podigy.
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In 2009, an old man died in a California nursing home. His obituary included not just his given name, but a long list of the pseudonyms he’d been known to use. In this classic 2019 episode, we trace the life of Riley Shepard, a hillbilly musician, writer, small-time con man and, perhaps, a genius. Then, on Your Questions Answered, psychologist Leslie John returns to answer your questions about when to share a secret, and when to keep it to yourself.
You can find an online version of Riley Shepard's Encyclopedia of Folk Music here.
There's a powerful tool almost all of us overlook when we're trying to improve a work project or help our kids with their homework. Learn more in this video on our new YouTube channel! Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
This is the abbreviated version of Checkup's call-in where we ask whether private menopause clinics are providing necessary treatments or promoting a two tier system? Private options are popping up across the country while many women face long wait-lists to find the right care.
As we mark Mother's Day this weekend, ICYMI digs back into the archives from a show that aired on Mother's Day back 1988. Many young women at the time were pushing back against the idea that they -- like their mothers -- would be at home with the kids and managing the household. Callers weighed in on the question: do all women eventually become their mothers?
Manitoba could become the first place in the world to ban AI chatbots for kids. While Australia has banned social media for youth under 16, Manitoba says regulation would include AI chatbots like ChatGPT and Claude. We hear from experts, parents and young people about what they think of the idea.
A new Ipsos survey found that 1 in 3 women will have to wait for more than 2 years to find effective treatment for menopause. To fill that need, private menopause clinics are popping up across the country. We hear from patients and practitioners about the rise of these private options in a country known for public healthcare.
