04:41 <whitequark> so uh
04:41 <whitequark> if any of your trans friends ever looks suicidal for no reason, the first thing you should scream at them is "are you *totally* sure your estradiol levels are where they should be"
04:48 <whitequark> because now I'm certain beyond doubt that this results in an apathy of the "standing up is literally an accomplishment" level
04:49 <whitequark> also why oral estradiol sucks; because of the exponential decay and I *think* the way receptors adjust to a baseline, at least in my case, that means I experienced a mild form of that every morning and evening before switching to patches
04:49 <whitequark> (though I'm surprised this isn't noticed by more people)
10:25 <whitequark> specifically it is enough to have a drop in e2, *regardless of what the initial/final levels are*
10:25 <whitequark> assuming they are over some threshold
10:26 <whitequark> now obviously the outcome is different but the receptor is the same
10:26 <whitequark> and based on the timescale of this mood disorder (~2h from "standing up is an accomplishment" to "actually I finished this old Rust pull request") this would be the nuclear ER action